40th Meeting of the
European Teratology Society
2 – 5 September 2012, Linz, Austria
In collaboration with ENTIS and EUSAAT
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Table of contents
Dear Friends and Colleagues,
On behalf of the Officers and Council of the European Teratology Society, it is my great honour and pleasure to invite you to the 40th Conference of the European Teratology Society-ETS at the Johannes Kepler University, one of the most famous Universities in Europe, in the city of Linz, Austria from 02 to 05 September 2012. At this meeting the ETS celebrates the 40th Meeting of the Society and we would like to welcome you to participate in this special event with an exciting Scientific Program in one of the most beautiful cities of Central Europe. The Scientific Program will be accompanied as usual with a social program promoting good interaction with your fellow delegates. The scientific program of the Conference reflects the opening of new and very interesting fields in Developmental Teratology and Toxicology, and the introduction of new methodologies and applications in modern embryotoxicity studies.
This year the Conference will be held together with the European Networks of Teratology Information Services-ENTIS Conference on August 31-September 2nd and a Satellite meeting by the European Society for Alternative to Animal Testing-EUSAAT which will follow the ETS Annual Conference on September 6 – 9, 2012 where the topic of “Animal Alternatives“ will include participants from the pharmaceutical, agrochemicals and industrial chemical arenas together with those from regulatory and academic institutions.
We encourage you to join and share your work at the conference and enjoy both the excellent scientific discussions and the wonderful atmosphere of this beautiful University City.
The main symposia will cover the following topics:- Joint ETS-ENTIS Symposium: "Disease Biomarkers"
- ETS Young Scientists Symposium
- ETS Symposium: "Experimental Reproductive Toxicology: (form to function)"
- Joint ETS-EUSAAT Symposium: "Animal Alternatives"
The programme also includes the ETS-Teratology Society debate on "Hazard vs. Risk-Based Approaches to Regulation?" the ETS and Elsevier Award Lectures, free communications and a poster session. The education course "Right Thinking – Right Answers!!" will focus on the topic of Study Interpretation and Data Analysis.
For this special 40th Annual Conference, the ETS is preparing a Celebratory Booklet including ETS pictures and recollections from those 40 years which will be provided to all ETS 2012 Conference registrants.
Linz is one of the most beautiful Austrian cities and located in the northern centre of Austria, on both sides of Danube river. The city was founded by the Romans, who called it Lentia and was first described as the provincial capital of Austria in 1490. Special highlights are the beautiful baroque facades of the buildings. Historical buildings, impressive churches and one of the largest medieval main squares in Central Europe conjoin with striking contemporary architecture to form an extraordinary city image.
Come to Linz, join with colleagues from the 40 years of ETS history and be surprised by the varied faces of the city during the day and night!
Looking forward to welcoming you in Linz, Austria on September,
Elpida-Niki Emmanouil-Nikoloussi
On behalf of the Organising Committee of the 40th ETS Conference
Society Officers
| Graham Bailey | President | Janssen Pharmaceutica, Belgium |
| Elpida-Niki Emmanouil Nikoloussi | Vice-President | Aristotle University, Thessaloniki, Greece |
| Nina Hallmark | Vice-President-elect | Exxon Mobil, Belgium |
| Ulla Hass | Past President | National Food Institute, Denmark |
| Shay Giles | Treasurer | University College, Dublin, Ireland |
| Deborah Perks | Secretary | Covance Ltd. UK |
ETS Council 2011 – 2012
| Stephane Barbellion | Sanofi |
| Sue Makris | US Environmental Protection Agency |
| Steffen Schneider | BASF SE |
| Asher Ornoy | Hadassah Medical School, Hebrew University |
| Andre Wolterbeek | TNO |
| Simon Craige | AC Immune SA |
| Luc De Schaepdrijver | Janssen Pharmaceutica R&D |
| Manon Beekhuijzen | WIL Research |
Preliminary Programme overview
| Sunday 2 | Monday 3 | Tuesday 4 | Wednesday 5 |
|---|---|---|---|
| Registration ETS Council meeting |
Welcome address | Symposium Experimental Reproductive Toxicology: form to function |
ETS-EUSAAT Symposium Alternative Approaches in Reproductive Toxicity Assessment |
| ETS-ENTIS Symposium: Disease Biomarkers |
|||
| Free Communications | Free Communications | ETS Award Lecture | |
| Lunch, incl. Legends lunch | Lunch, incl. Open forum discussion | Lunch | |
| Education Course: "Right Thinking – Right Answers!!" |
Young Scientists Symposium | ETS-TS Debate: "Assessment of hazard vs. risk: A simple question with big implications" |
Start of EUSAAT Meeting |
| Poster reception and Poster session | Elsevier award lecture | ||
| Presentation of ETS 2013 conference | |||
| AGM |
Preliminary Programme
Sunday 2 September
| 09.00 – 13.00 | ETS Council Meeting |
| 14.00 – 17.30 | ETS Education course – "Right Thinking – Right Answers!!" Sponsored by Huntingdon Life Sciences Organizers: Graham Copping and Sue Makris |
| 18.00 | Young Scientists "Happy Hour" |
| 19.00 | Welcome reception, including light refreshments |
Monday 3 September
| 09.00 – 09.15 | Welcome address Graham P. Bailey |
| 09.15 – 11.30 |
ETS-ENTIS Symposium – Disease Biomarkers Organizer: Asher Ornoy and Elpida-Niki Emmanouil-Nikoloussi |
| 09.15 – 09.55 |
Biomarkers for diabetes and diabetic embryopathy Dr. Asher Ornoy, Hebrew, University Hadassah Medical School, Jerusalem, Israel |
| 09.55 – 10.30 | Biomarkers of teratogenesis: suggestions from animal studies Prof. Erminio Giavini, University of Milan, Italy |
| 10.30 – 11.00 | Coffee |
| 11.00 – 11.30 | Genetic susceptibility to teratogens: state of the art Prof. Mauricio Clementi, Medical School of the University of Padua, Italy |
| 11.30 – 12.30 | Free Communications |
| 12.30 – 14.00 | Lunch incl. "Legends Lunch" |
| 13.00 – 14.00 |
Young scientists Legends lunch Organizer: Nina Hallmark |
| 14.00 – 16.00 |
ETS Symposium 1 – Young Scientists Symposium Sponsored by WIL Research Organizers: Manon Beekhuijzen and Simon Craige |
| 14.00 – 14.20 |
Differential performance of Wistar Han and Sprague Dawley rats in behavioral tests: Differences in baseline behavior and reactivity to positive control agents Amy Zmarowski, WIL Research, The Netherlands |
| 14.20 – 14.40 |
The non-intubated, spontaneously breathing, continuous positive airway pressure (CPAP) ventilated pre-term lamb: a unique animal model Daniela Rahmel, Nycomed/Takeda, Germany |
| 14.40 – 15.00 |
Zebrafish embryotox and transcriptomics. Sanne A.B. Hermsen, RIVM, Bilthoven, The Netherlands |
| 15.00 – 15.20 | Coffee |
| 15.20 – 15.40 | 3D Atlas of the developing human Bernadette Bakker, Academic Medical Center, Amsterdam, The Netherlands |
| 15.40 – 16.00 | Short communications |
| 16.10 – 18.00 | Poster reception and Poster session |
| FREE EVENING | |
Tuesday 4 September
| 09.00 – 11.15 |
ETS Symposium 2 – Experimental Reproductive Toxicology: "Form to Function" Organizer: Ulla Hass and Andre Wolterbeek |
| 09.00 – 09.35 |
Structural and functional developmental immunotoxicology: an overview Dr. Andre Penninks, TNO Triskelion, Zeist, The Netherlands |
| 09.35 – 10.10 |
Disturbances in cardiac function during embryonic life: postnatal consequences Prof. Bengt Danielsson |
| 10.10 – 10.40 | Coffee |
| 10.40 – 11.15 |
Integrating morphological and functional outcomes in developmental neurotoxicity risk assessment Sue Makris, U.S. EPA |
| 11.50 – 12.30 | Free communications |
| 12.30 – 14.00 | Lunch |
| 13.00 – 14.00 | Open Forum discussion Organizer: Graham Bailey |
| 14.00 – 15.00 |
ETS-TS Debate – "Assessment of hazard vs. risk: A simple question with big implications" Chair: Chair: Susan Makris, USEPA/ORD/NCEA, Washington, USA Teratology Society: "The risky business of regulation" Linda Roberts, Chevron Energy Technology Company, California, USA European Teratology Society: "Caution – hazard! But should we worry" Graham P. Bailey, Janssen Pharmaceutica, Beerse, Belgium |
| 15.00 – 15.30 | Elsevier Award lecture |
| 15.30 – 15.45 | Presentation of ETS 2013 Conference |
| 15.45 – 16.05 | Coffee |
| 16.05 – 17.30 | ETS Annual General Meeting |
| 19.30 – late | ETS dinner |
Wednesday 5 September
| 09.00 – 12.00 |
ETS Symposium 3 – Alternative Approaches in Reproductive Toxicity Assessment Organizers: Aldert Piersma |
| 09.00 – 09.35 |
"In vitro modelling of spermatogenesis" Prof. Dr. Stefan Schlatt, Münster, University, Germany |
| 09.35 – 10.10 |
"The zebrafish embryo model for embryotoxicity testing" Dr. Stefan Scholz, UFZ-Helmholtz Centre for Environmental Research, Germany |
| 10.10 – 10.40 | Coffee |
| 10.40 – 11.15 |
"Transcriptomics applications in in vitro embryotoxicity assessment" Dr. Ilse Tonk, RIVM, Bilthoven, The Netherlands |
| 11.15 – 11.50 |
"Computational toxicology and in silico modelling of embryogenesis" Dr. Thomas Knudsen, USEPA Research Triangle Park, NC, USA |
| 12.00 – 12.45 |
ETS Award lecture Speaker to be confirmed |
| 12.45 – 13.00 | Farewell address, Elpida-Niki Emmanouil-Nikoloussi |
| 13.00 – 14.00 | ETS Council Meeting |
Satellite Meeting EUSAAT Annual Meeting
It gives us great pleasure to announce that this year’s ETS meeting will be held in association with the EUSAAT meeting in Linz.
Wednesday 5 September
The 14th Annual Congress of EUSAAT (the European Society for Alternatives to Animal Testing) will run from the afternoon of Wednesday 05 till Saturday 08 September 2012 and will include a combined day on the 05th in collaboration with the ETS.
EUSAAT is dedicated. to the promotion of research in the field of the 3Rs (refine, reduce, replace), the reduction of suffering and stress of laboratory animals by better breeding, keeping, test planning and other accompanying measures, the reduction of the use of animals for tests in the field of education and continuing education and the dissemination and validation of alternative methods to animal testing. It also provides expert guidance for public and private organizations, and universities.
Lectures and posters can be submitted for the following topics:-
Replacing animal models in basic research
(e.g. transgenic animals, xenotransplantation, specific disease models, teratoma assays to prove pluripotency of stem cells) -
Implementing of the Directive 2010/63/EU on the protection of animal used for scientific purposes
(incl. position of the EU Commission, of EU member states and of animal welfare organisations, examples for the implementation) - 7th amendment of EU Cosmetics Directive: deadline 2013 – current situation and new developments
- Evaluation of the two ECHA reports on REACH 2011 – consequences and new developments
-
Replacing animal bioassays for toxin and vaccine testing
(e.g. BoNT testing, shell fish toxin, vaccine testing) - Toxicology of nano-materials
- Environmental toxicology
- Progress reports from EU FP6 & FP7 projects on alternatives
- Ethical and & legal issues
- Funding of research on alternatives
- Free communications
The online submission form will be opened until 15th February 2012!
Deadlines for the submission:- submission of lectures: 30th April 2012
- submission of posters: 31st May 2012
For the latest information, please see the Society website at http://www.eusaat.org
Call for Abstracts
Participants interested in giving an oral or poster presentation are invited to submit an abstract. You are especially encouraged to send in work on topics related to the main symposia ("Disease Biomarkers", Experimental Reproductive Toxicology: "Form to Function" and Alternative Approaches in Reproductive Toxicity Assessment) or the education course and ETS/TS Discussion ("Assessment of hazard vs. risk") which can be given as free communications.
The maximum size of posters is 1200 mm wide x 1500 mm high
Abstracts received before April 1st will be published in "Reproductive Toxicology". Abstracts received after that date will be published in the handbook to be distributed at the meeting.
If you do not have e-mail facilities, send your abstract in MS Word on a CD Rom plus printout to the Organization Secretariat.
Abstract template:
Authors names in bold, with full first name and second initial, and presenting author with asterisk after surname.
Affiliation in italics, name of institute, place and country only. With more than one affiliations indicate by superscript numbers and match with superscript numbers after surnames.
One line spacing before body text.
Abstract body in plain text in one paragraph, no indents or empty lines. No figures or tables, up to three references acceptable. Organize text in: introduction, methods, results and conclusions. Provide factual text. Avoid general statements like: "results will be presented". Use 300 up to a maximum of 500 words for complete abstract text (including title, authors, affiliation and body text).
Add preference choice for poster or oral presentation.
Abstract deadline: April 1st, 2012
Please email abstracts to: gbailey1@its.jnj.com, emmanik@med.auth.gr
ETS/Elsevier Prizes
In addition to the ETS Award Lecture which is given by a long-standing and well respected member of the Society and the Elsevier Reproductive Toxicology Publication Award Lecture, which is awarded to the best publication in the Journal of Reproductive Toxicology in 2010, there are four prizes: the ETS Prize, two Elsevier Prizes and the Teddy Edward’s Memorial Prize for Research into Congenital Malformations, awarded to the poster or free communication which best exemplifies the aims of the Society.
ETS student travel grants
A limited number of ETS student travel grants (250 E) are available. To qualify for a travel grant, students must submit an abstract for presentation at the conference and apply for membership to the Society. Applications should be made by the student´s Supervisor to the Secretary of the ETS.
Education course
The Education Course this year is entitled "Right Thinking – Right Answers!!": Study Data Analysis and Interpretation. The Course will be appropriate for both experienced Reproduction Toxicologists and those with an interest in developmental toxicology and will focus on the variability and impact of data use and interpretation. No extensive knowledge of statistics or study design is necessary!
We hope that you will find the Course informative, interesting and enjoyable.
Social Programme
Welcome reception in the City – with light refreshments.
This will be preceded by: Young Scientists "Happy Hour"
An informal get together to meet new and old friends and to promote networking opportunities.
ETS Conference dinner
We would like to invite you to join us at the conference dinner on Tuesday evening. It will
take place in a beautiful and traditionally Austrian restaurant above the city of Linz.
Dress, casual.
Accommodation
Rooms are available at the following hotels:
| Category | Hotel | Room rates in EUR per room / per night / incl. breakfast |
Distance to Kepler University | |
|---|---|---|---|---|
| Single room | Double room | |||
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Arcotel Nike | 134,00 € | 134,00 € | 10 min by public transportation |
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All Seasons / IBIS Styles | 89,00 € | 109,00 € | 30 min by public transportation |
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Park Inn by Radisson | 105,00 € | 125,00 € | 15 min by public transportation |
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Sommerhaus | 47,00 € | 86,00 € | 5 min walk |
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St. Magdalena Bildungszentrum | 53,00 € | 86,00 € | 5 – 10 min by car |
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Youthotel | 43,00 € | 61,00 € | 30 min by public transportation |
Please visit the website https://events.kuoni-dmc.com/ei/images/Hotels/Linz/hotel_EUSAAT2012_eng.htm for more information about available hotels.
For reservation please use the following link: https://events.kuoni-dmc.com/ei/getdemo.ei?id=312&s=_DFS0RYYOD
ETS Annual Meeting Registration
To register for the ETS Annual Meeting please use the registration form.
Using this form you will be able to pay directly via credit card (American Express, Master Card and Visa Card).
Registration fees
Until June 30, 2012
| ETS Members | € 345.00 |
| Non Members | € 420.00 |
| Students* | € 100.00 |
After June 30, 2012
| ETS Members | € 410.00 |
| Non Members | € 485.00 |
| Students* | € 130.00 |
Above fees include all ETS lectures, free communications, lunch, welcome reception and ETS Conference dinner.
One-Day registration
Until June 30, 2012
| ETS Members | € 105.00 |
| Non Members | € 136.50 |
| Students* | € 52.50 |
After June 30, 2012
| ETS Members | € 126.00 |
| Non Members | € 157.50 |
| Students* | € 63.00 |
One-Day fees include the ETS lectures, free communications and lunch for the registered day.
Education Course
Until June 30, 2012
| ETS Members | € 70.00 |
| Non Members | € 100.00 |
| Students* | € 40.00 |
After June 30, 2012
| ETS Members | € 100.00 |
| Non Members | € 130.00 |
| Students* | € 60.00 |
* Students registration to be supported by letter of supervisor.
ETS Conference Registration
Accompanying Person| Until June 30, 2012 | € 100.00 |
| After June 30, 2012 | € 100.00 |
Fee includes welcome reception and ETS Conference dinner. Participation in the scientific sessions is not included.
The fees quoted are exclusive of VAT (21 %) and a VAT receipt will be issued to permit your
VAT registered company to reclaim this additional cost
Organization
Solution office e.K.Pia Schröder
Bergstr. 2
29646 Bispingen
Germany
Tel.: +49 5194 97449-0
Fax: +49 5194 97449-4
e-mail: congress@solution-office.de
Cancellation and Refund Policy
Cancellations are to be notified in writing to the ETS Conference Organizing office. Refunds will be made under the following conditions:- You may cancel at no penalty within 48 hours of placing your registration.
- Until 1 August, 2012 a 60 % refund of the registration fee will be given.
- After 1 August, 2012, no registration fees will be refunded.
All refunds will be handled after the Conference.
How to get to Linz?
By car
Linz is almost in the middle of the freeway A1 from Salzburg to Vienna (140 km to Salzburg and 200 km to Vienna). Take freeway A1 (from Salzburg to Vienna or vice versa) until "Knoten Linz". Take freeway A7 from "Knoten Linz". Follow the signs in the direction of "Freistadt, Prag" (about 15 km). Get off at the exit "Linz-Dornach". About 2 km before the exit "Linz-Dornach" the freeway crosses the Danube.
By Train
When arriving by train at the main train station in Linz, there are 2 tram lines with good connections with the Johannes Kepler University. Trams run every 5 to 7 minutes and it takes about 30 to 45 minutes. You can buy the ticket at ticket machines at the stops. Take Line 3 at the main train station and change to Line 1 (direction "Universität" – last station on the line). You can change the tram at the first stop ("Blumauerplatz"), but you do not need to hurry. Line 1 and Line 3 use the same track through the center of Linz. The last stop where it is possible to change is "Rudolfsstrasse" (right after crossing the Danube). Go on until the last stop "Universität".
By Plane
The Blue Danube Airport in Hörsching is about 15 km away from the city of Linz. Links to the city are:
- Bus to the main train station in Linz: The bus (red color) from the airport to the main station only leaves at 06.00, 08.00, 10.00, 12.00, 14.00, 16.00, 18.00, 20.00, 23.10 and then continue by tram.
- Shuttle service to the next train station (Hörsching), train to the main train station of Linz: The shuttle service is free. Then continue with by tram.
- Alternately, you can fly to the better-connected Vienna or Salzburg airports and take the train to Linz. There are trains almost every hour from Vienna to Linz. To check the schedule please go to the following webpage: http://www.oebb.at/en/
Congress venue
Johannes Kepler University (JKU) Linz
Unicenter Altenberger Str. 69
4040 Linz
Austria
Climate in Linz
From May to September the average maximum temperatures vary between 18°C and 23°C, and the minimum temperatures between 8°C to 13°C.
Language
The majority of the population speak local Austro-Bavarian dialects of German as their native language, and German in its standard form is the country’s official language.
Currency & exchange
Austria is a member of the Economic and Currency Union and the common currency is the Euro. Currency can be exchanged at banks and bureaux de change available in all towns, but it may be easier to use the ATMs. Banks are closed on Saturdays and Sundays, but exchange offices at airports and major city rail terminals are open seven days a week. Major credit and debit cards are widely accepted though some small hotels and restaurants may only accept cash. Travellers cheques are also accepted.
Sponsors & Exhibitors

